Conference Day One - Wednesday | July 10, 2024

7:50 am Check-In & Coffee

8:50 am Chair’s Opening Remarks

Evaluating Promises & Challenges to Propel In Vivo Approaches as the Definitive Solution

9:00 am Industry Leader’s Fireside Chat: Supercharging In Vivo as the Frontier of Cell Therapy & Comparing to Ex Vivo


  • Accentuating the bottlenecks of ex vivo therapies, such as the need for costly manufacturing processes and limited access, to consider the need to move towards a new engineering technique
  • Championing in vivo therapies by highlighting the solutions they could bring to the ex vivo cell therapy and gene editing field
  • Reaffirming the shift of interest towards in vivo therapies as the reality of clinical progression comes to the forefront

10:00 am Morning Break & Speed Networking


As this community re-unites for the third time, this session will provide valuable networking time with your peers, enabling you to forge new and lasting connections.

Optimizing Target Specificity to Minimize Off-Target Toxicity & Prioritize Safety, Allowing Progression Towards Clinics

11:00 am Exploring Target Specificity to Avoid Off-Target Toxicities & Increase Safety of In Vivo Therapies

  • Marc Güell Head of Translational Synthetic Biology laboratory, Argobio Studio


  • Reflecting on data to clarify the current methods of accurately evaluating off-target effects
  • Exploring the importance of avoiding genome toxicity and exploring strategies to measure reproductive risk
  • Addressing off-target effects of treatments on genes critical to development, and how safety in children could be measured in models

11:30 am Panel Discussion: Improving Target Specificity by Reviewing Methods to Reduce Off-Site Effects & Innovations Needed to Increase Target Precision


  • Identifying challenges in target specificity to collaboratively review current techniques
  • Assessing the advantages and disadvantages of each method to improve target specificity
  • Planning for future improvements and driving new innovations to elevate target specificity

12:15 pm Lunch Break & Networking

Finding the Balance Between Efficacy & Toxicity to Secure Safe & Promising Outcomes

1:15 pm Examining Efficacy of In Vivo Treatments & Sharing Pre-Clinical Data


  • Addressing clinical CAR-T indications, efficacy signals, the need for lymphodepletion, effective doses, toxicities, and correlatives (integrations per cell, durability, exhaustion etc.)
  • Evaluating the performance of in vivo generated CAR-T cells in well-known pre-clinical models to allow us to predict likely clinical superiority

1:45 pm Roundtable Discussion: Exploring How Efficacy & Toxicity Link with Drug Exposure


  • Understanding connections between increased drug exposure and increased efficacy in models
  • Discussing the optimal drug exposure to balance off-site toxicity with increased efficacy

2:15 pm Afternoon Break & Poster Session


This is your opportunity to contribute to the conversation and share your cutting-edge research with this community, while also discovering exciting work carried out by your peers. To submit a poster, please contact

Discussing Innovations in Platform Development: CAR-M Therapies & Administration Methods

3:15 pm Reprogramming Myeloid Cells for Cancer: CAR-M from Ex Vivo to In Vivo


  • Targeting macrophages with CARs for solid tumors
  • Investigating pre-clinical and clinical data with ex vivo CAR-M cell therapies
  • Describing our in vivo CAR-M platform that is being developed in partnership with Moderna

3:45 pm Lessons Learned from Intravenous Administration of Gene Delivery Vehicles for In Vivo Cell Engineering

  • Nicholas Boyle Founder, President, Chief Executive Officer & Director, Abintus Bio


  • Exploring intravenous administration of gene delivery vehicles to inform the development of in vivo CAR-T
  • Scaling the manufacturing of products for intravenous administration
  • Examining the role of synthetic biology to achieve the targeting precision required for in vivo cell engineering

4:15 pm Chair’s Closing Remarks

4:25 pm End of Conference Day One