In Vivo Generation Of TRAC-CAR-T Cells By Leveraging Enveloped Delivery Vehicles
- T cell-specific delivery and genomic site-specific genome editing enables potent and safe in vivo CAR-T cell generation
- Precise genomic integration of the CAR behind the endogenous TRAC promoter enables homogenous CAR-T cell generation with enhanced potency from native regulation
- In vivo CAR-T cell efficacy and tolerability across numerous clinically relevant models support progression toward first in human readiness