In Vivo mRNA-LNP CAR-T Cells Targeting Mast Cells for Mast Cell-Driven Diseases, Severe Allergies & Anaphylaxis
- Defining the unmet medical need that can be fulfilled with an in vivo CAR-T approach
- Ideal features necessary for a safe and effective mast cell target
- Design and function of novel mRNA-LNP CAR constructs targeting human mast cells